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    gtf2h1 general transcription factor IIH, polypeptide 1 [ Danio rerio (zebrafish) ]

    Gene ID: 447857, updated on 27-Mar-2024

    Summary

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    Official Symbol
    gtf2h1provided by ZNC
    Official Full Name
    general transcription factor IIH, polypeptide 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040912-164
    See related
    Ensembl:ENSDARG00000026701 AllianceGenome:ZFIN:ZDB-GENE-040912-164
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92126
    Summary
    Predicted to be involved in nucleic acid metabolic process and phosphorylation of RNA polymerase II C-terminal domain. Predicted to act upstream of or within nucleotide-excision repair and transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIIH core complex and transcription factor TFIIH holo complex. Orthologous to human GTF2H1 (general transcription factor IIH subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 25
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (3196855..3217115, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (3071111..3091371, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene RAB3A interacting protein (rabin3)-like 1 Neighboring gene eosinophil peroxidase Neighboring gene HPS5 biogenesis of lysosomal organelles complex 2 subunit 2 Neighboring gene RCC1 domain containing 1 Neighboring gene calcium and integrin binding 1 (calmyrin) Neighboring gene methionyl aminopeptidase 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary conservation of TFIIH subunits: implications for the use of zebrafish as a model to study TFIIH function and regulation. Silva IA, et al. Comp Biochem Physiol B Biochem Mol Biol, 2014 Jun-Jul. PMID 24731924
    2. Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. Le MT, et al. PLoS Genet, 2011 Sep. PMID 21935352, Free PMC Article
    3. Gene duplication followed by exon structure divergence substitutes for alternative splicing in zebrafish. Lambert MJ, et al. Gene, 2014 Aug 10. PMID 24942242
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Xenophagy receptors Optn and p62 and autophagy modulator Dram1 independently promote the zebrafish host defense against Mycobacterium marinum.
      Title: Xenophagy receptors Optn and p62 and autophagy modulator Dram1 independently promote the zebrafish host defense against Mycobacterium marinum.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor IIH subunit 1
    Names
    p62
    zmp:0000000569

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004596.1 → NP_001004596.1  general transcription factor IIH subunit 1

      See identical proteins and their annotated locations for NP_001004596.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081602
      UniProtKB/TrEMBL
      A0A8M1N2C2, Q66I03
      Related
      ENSDARP00000038901.5, ENSDART00000032390.6
      Conserved Domains (3) summary
      smart00751
      Location:101 → 153
      BSD; domain in transcription factors and synapse-associated proteins
      cd13229
      Location:9 → 102
      PH_TFIIH; Transcription Factor II H (TFIIH) Pleckstrin homology (PH) domain
      pfam03909
      Location:181 → 236
      BSD; BSD domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      3196855..3217115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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